Abstract: The effect of three tillage methods (No-till, NT; Plough, P and Plough and harrow, (P+H) and the efficacy of Rimsulfuron (N-(4,6-dimethoxyl-2-pyrimidinyl) (amino carbonyl)-3-(ethysulfonyl)-2-pyridinesulfonamide) applied at 30 g ai ha-1, Codal gold (a formulated mixture of metolachor (2-chloro-N-(2-ethyl-6-methylphenyl)-N-)2-methoxl-1-methyethyl) acetamide) and prometryn (N,N`-bis(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine) applied at 1.23 kg ha-1 on weed regeneration in maize (Zea mays L.) was studied at the University of Benin, Benin City, Faculty of Agriculture farm. The experiment was a split-plot arrangement in a completely randomized block, with tillage methods as the main treatment and weed control methods (Rimsulfuron, RIM; Codal Gold, CG; No weeding NW; HW) as sub treatment. Tillage methods significantly influenced weed biomass (1556, 980.12 and 1024.57 kg ha-1 for NT, P and P+H respectively, (p<0.05), but there were no significant differences in weed biomass between P and P+H. Weed control methods also significantly affected weed biomass, 1153.12, 1048.49, 1010.04 and 1535.91 kg ha-1 for CG, HW, Rim and NW, respectively (p<0.05). Tillage and weed control methods significantly influenced maize plant height and dry matter. Tillage methods significantly affected maize grain yield with values of 801.37, 1131.55 and 1272.37 kg ha-1 for NT, P and P+H, respectively. Codal Gold significantly depressed grain yield irrespective of the tillage system.