Abstract: Objective: This study aimed to analyze the role of network and business strategy as mediator variables affecting the relationship between entrepreneurial orientation (EO) and enterprise growth, in small-scale poultry layer enterprises. Materials and Methods: This study utilized questionnaire to obtain data from 150 small-poultry layer farms in South Sulawesi Province, Indonesia and to run the path model of independent variable (entrepreneurial orientation), intervening variable (network and types of business strategies) and dependent variable (growth of small poultry layer farms). Results: The results of the study show that the EO has positive and significant relationship with the network and the business strategy but it is not significant with the enterprise growth. The results of the study also show that the network and business strategy as moderating variable can enhance the contributing effects of the EO on the enterprises growth. From both mediator variables, the contributing effects of the network tend to be larger than business strategy. Conclusion: Network plays pivotal roles in moderating the relationship between the EO and the enterprises growth.