Abstract: Background and Objective: Moringa oleifera is one of the local food ingredients with adequate nutrient content to act as an antioxidant, hypocholesterolemia and cardiac stimulant. This research was designed to study the effect of supplementation of moringa leaf powder, on reproductive performance and ovarian morphometry of Pengging ducks. Materials and Methods: The study used a complete randomized design, with a total of eighty female Pengging ducks, 24 weeks old divided into five treatment groups and four replicates of each. The first group (control) was fed basal diet, without the supplement of moringa leaf powder, while the second to the fifth group was fed a basal diet with 2.5, 5, 7.5 and 10% Moringa leaf supplementation. Results: Age of sexual maturity was 2-3 days faster in the duck fed diet supplemented with 2.5-10% Moringa leaf powder. Concentrations of serum glucose, cholesterol and LDL were lower (p<0.05) in the group fed with moringa leaf supplement, although serum HDL and protein concentrations increased (p<0.05). MDA level of the liver ducks were significantly influenced (p<0.05) by moringa leaf supplement, as the diameter of F1 and F2 follicles, increased (p<0.05) in the groups fed diet supplemented with moringa leaf powder. Conclusion: The moringa leaf powder supplementation of 2.5-10%, improved the reproductive profile of the Pengging ducks which was supported by an increased in diameter of F1 and F2 follicles, without an increase in the serum cholesterol and MDA of the liver and ovary concentrations. Hence, moringa leaf powder was significant as a hepatoprotector and oviprotector, in sexually mature Pengging ducks.