Abstract: Probiotics are widely accepted as an alternative to in-feed antibiotics in poultry production. So far, the frequently used microorganisms in probiotics are strains of lactic acid producing bacteria having specificity of adhering to the intestinal epithelium. Recently, a probiotic containing novel strain such as Aspergillus oryzae is also in practice, but its effect on performance of poultry is limited. The present review explored Aspergillus oryzae as the potential candidate for probiotic.