Abstract: The study was conducted to ascertain the effect of "Norponin 200 Liquid" on urease activity and development of ascites in broiler chickens. Two commercial broiler rations were prepared containing 2810 Kcal/kg metabolizable energy and 20 % crude protein starter and 2900 Kcal/kg metabolizable energy and 18.50 % crude protein, finisher ration. 240 chicks were divided into four groups i.e. A, B, C and D, respectively. Each group had 60 birds and groups were further subdivided into 6 replicates having 10 birds each. Each group offered different concentrations of Norponin 200 Liquid. Group A was control group i.e. without medication. Groups B, C and D were offered 2.5, 5.0 and 7.5 ml Norponin 200 liquid/100 liter of drinking water, respectively. The data regarding feed consumption, weight gain, FCR, urease activity inside the intestine and in the excreta, mortality and economics were recorded. It was concluded that group D offered Norponin 200 Liquid at 7.50 ml/100 liter of drinking water had comparatively better results than groups B and C offered 2.5 ml and 5.0 ml Norponin 200 liquid/100 liter of drinking water and control group A.