Abstract: The leaf of mulberry (Morus spp.) constitutes the only food to silkworm (Bombyx mori L.). Like all other crops, it is prone to attack by a number of pests and diseases which result in reduced leaf yield and quality. Among other diseases leaf spot and powdery mildew are important and cause much loss to mulberry leaf. Besides other defence systems, the plants defend themselves against pathogens by means of structural characteristics which act as physical barriers and inhibit the pathogen from gaining entrance and spreading through the host. Morphoanatomical features of some mulberry genotypes were studied in relation to incidence and intensity of leaf spot caused by Cercospora moricola (Cooke) and powdery mildew caused by Phyllactinia corylea. The present study was carried out on four years old mulberry trees of genotypes namely Goshoerami, Ichinose, Kairynezamigaeshi (KNG), Rokokuyaso, Chinese White, Tr-10 and one local genotype Chattatul Zangir for leaf spot and powdery mildew diseases. The Percent Incidence (PI) and Percent Disease Index (PDI) were calculated. Different anatomical features were studied as per standard laboratory methods. Results indicated that the anatomical features play an important role to hinder the infection and spread of the pathogens causing the diseases and hence can be used for rapid screening of mulberry genotypes for their resistance to these diseases.