Abstract: Black pod and Canker caused by Phytopthora palmivora and Phytophthora megakarya and Cocoa Swollen Shoot Virus Disease (CSSVD) caused by cocoa swollen shoot virus are important diseases of cocoa in Ghana. Host plant resistance has been considered the most effective method of controlling these diseases. This study was initiated to determine whether multiple forms of resistance to these diseases could be identified in hybrids of cocoa. Thirty six crosses of 6x6 diallel mating design of cocoa were screened for resistance to black pod (P. palmivora and P. megakarya), CSSVD (severe New Juaben CSSV Strain 1A and Nsaba CSSV strain) and Phytophthora canker (P. palmivora and P. megakarya) under a controlled environment. Of the thirty six crosses, 12, 6 and 7 were resistant to black pod, cocoa swollen shoot virus disease and Phytophthora canker, respectively. No cross was found to have combined resistance to the three diseases. This indicates that selection and breeding of cocoa genotypes for multiple disease resistance based on phenotypic data alone could be difficult. Marker assisted selection using tightly linked gene-specific molecular markers will play a larger role in future studies and could be an asset in working with quantitative resistance systems. Cocoa hybrids Alpha B36xPa7/808, Pa7/808xPound 7 and Alpha B36xT65/326 which possess high levels of resistance to more than one disease were identified through this study and would be useful in cocoa multiple disease resistance breeding programmes.