Abstract: The objective of this study was to observe pattern of similarity of reaction to Phytophthora palmivora infection among 25 international cocoa genotypes in five laboratory experiments and a field observation at the Cocoa Research Institute of Ghana by hierarchical cluster analyses. The genotypes were clustered into two distinct populations in all the screening methods suggesting of genetic limitations of the cocoa genotypes studied. The hierarchical cluster analyses of all the screening tests sub-clustered the susceptible and resistant clones differently except in field infection where there was some inconsistency. This is indicative of the possibility of using any of the screening methods to observe similarity of reaction of cocoa genotypes to Phytophthora species. The inconsistencies in field infection are suggestive of the environmental factors influencing the genetic base of infection of Phytophthora species in the field. The resistant and susceptible genotypes were distributed among centres of origin and genetic groups showing that resistant and susceptible genotypes were widely dispersed among origins and genetic groups. The shapes of pods of resistant genotypes were made up of calabacillo and cundeamor while that of susceptible clones was Amelonado. The remaining of the clones, classified as moderately resistant were the most distantly related clones.