Abstract: Background and Objective: Diabetes mellitus is recognized as a global pandemic and is recently linked to cognitive and memory decline. In this study effect of Aqueous Sukkari Dates Seeds Extract (ASSE) on Type-2 Diabetes Mellitus (T2DM) associated neuroinflammation was explored. Materials and Methods: About 30 Sprague Dawley Male rats were divided into 5 groups with 6 rats each. Four groups of rats were induced with T2DM using nicotinamide and Streptozotocin (STZ), while one was considered as control. Among the 4 groups, two were treated with oral doses of 200 and 400 mg kg–1 of ASSE, the 3rd group was treated with standard drug metformin while the 4th group was left untreated and considered as diabetic-induced. The treatment with ASSE and metformin was continued for 30 days. At the end of treatment, the brain tissue was isolated and estimated for the neuroinflammatory parameters like TNF-α, IL-6, IL-10, TGF-β1 and COX-2. Results: The 2 doses of ASSE resulted in a significant decrease of COX-2 levels besides resulting in the decrease of proinflammatory cytokines like TNF-α and IL-6 levels. The administration of ASSE also increased an anti-inflammatory cytokine, IL-10 levels. Conclusion: The results support the neuroprotective effects of ASSE. Besides, it can also be concluded that the ASSE also has the potential to improve the cognitive deficit in T2DM patients.