Abstract: Of the drugs consumed in the hospital wards, analgesics are the first in place with 35.43%. The purpose of the present paper was to know if analgesics attenuate multi-tissue oxidative damage via the activation of antioxidative activities, anti-inflammation and anti-apoptosis and their roles in improving functional outcomes. Assays of some biomarkers such as Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), Glutathione (GSH) and Glutathione Peroxidase (GSH-Px) have provided inalienable evidence of these analgesic effects. The treatment with analgesics, in general, have demonstrated to attenuate oxidative stress and inflammation, with a decreased level of MDA and NO and a decreased expression of NF-κB and cyclooxygenase-2 (COX-2). The use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) also increases Nrf2 protein and Heme Oxygenase-1 (HO-1) protein expressions, antioxidant enzymes and SOD activity. Moreover, the treatment with analgesics decreased the apoptotic potentials of the biomarkers, which is in line with the tunnel assay. In this work, we analyzed the changes in the antioxidant status of analgesic drugs and the role of these in improving functional outcomes. Moreover, we investigated if analgesic use offered protection against oxidative damage present in several diseases.