Abstract: Background and Objective: Amnesia is one of the major complications associated with memory loss in the patents of neurodegenerative disease like Alzheimer’s disease (AD). The present study investigated the potential of Leea indica extract in amnesia of Alzheimer’s type induced in by scopolamine rats. Materials and Methods: Scopolamine was administered at a dose of 3 mg kg–1, i.p. (One time before and after to study anterograde and retrograde amnesia) to rats for four days and then divided into different groups. Group I considered as control, Group II as Negative control, Group III animals represented Piracetam (120 mg kg–1, i.p.) treated group and Group IV were administered the dose of 500 mg kg–1 (p.o) of methanolic extract of Leea indica (MELI), followed by scopolamine after 45 min. All the animals after 30 min of scopolamine administration were subjected to morris water maze test. On last day of trial, all animals were dissected and subjected to estimate different biochemical estimations like superoxide dismutase (SOD), catalase. AchE, TNF-α and mono amine oxidase (MAO-A and MAO-B) were also estimated. Results: Scopolamine produced a marked decline in escape latency time and increased the TNF-α in both retrograde and anterograde amnesia and also effect on various other biochemical parameters of brain and brain tissues. The MELI act as MAO-B inhibitor and effected on TNF-α, acetylcholine esterase enzyme, in cognitive dysfunctions associated with experimental amnesia in rats. The MELI and Piracetam treated animal showed reduction in AchE and elevation SOD and catalase in retrograde and anterograde amnesia. Conclusion: So this study concluded that MELI significantly modulated the induced memory deficits, biochemical alterations.