Abstract: Cancer is an alarming condition whose occurrence has increased dramatically in the last few decades. This, in turn, has increased the medicinal cost and health care burdens of society. Unfortunately, a lack of effective and safe pharmacological therapy and strategies has been found to overcome this issue. Now-a-days nose cancer is an alarming health disorder that requires scientific attention to find an effective and safe pharmacological approach to overcome this serious issue. Currently, various treatments are used for this life threatening disease. Chinese traditional medicine like ginseng is one of the choices used as an effective and safe therapeutic tool for the treatment of cancer. Some previously published studies proved that ginseng not only kills the cancer cells but also inhibits the further multiplication of cancer cells with minimum side effects compared to the rest of treatment therapies. However, the exact mechanism of action behind ginseng’s ability to kill cancer cells has not been completely explored, there are still many research areas waiting to be studied, such as molecular pathways involved in the ginseng-derived flavonoids that attack cancer cells. The target of this review is to highlight the importance of the medicinal effects of ginseng and their flavonoids used in cancer therapy. Another objective of this paper is to attract the attention of the scientific community, to find out the mechanism of action behind ginseng herbal medicine in order to develop safe and non-toxic drugs for the cure of nose cancer.