Abstract: Background and Objective: Medicinal plants are widely used as home remedies and raw materials for the pharmaceutical industries. The influence of dietary supplementation of black seed (Nigella sativa) and turmeric (Curcuma longa Linn.) on serum IL-6, growth performance parameters and feed utilization efficiency of Albino rats diets was investigated. Materials and Methods: In this study a total of 45 Albino rats were allotted into three equal treatments with five equal replicates for each throughout the experimental period (40 days). The rats in the first treatment fed on basal diet and served as a control while rats of the second and third treatments kept on basal diet contained 0.5% black seed and 0.5% turmeric, respectively. Results: Diet containing black seed and turmeric cleared a significant increase in final body weight, feed conversion ratio, reduced feed intake and immunological parameters when compared with the control group. Where experimental group contained 0.5% black seed was the best followed by that containing 0.5% turmeric. Conclusion: Dietary inclusion of black seed and turmeric relatively improved the growth performance, feed utilization efficiency and interleukin 6 (IL-6).