Abstract: Background and Objective: Postmenopausal women frequently have osteoporosis due to deficient estrogen secretion. Phytoesteroids are natural alternatives, of plant origin, can play the role of estrogen substitute in menopause. This study was planned as a trial to formulate a novel safe seeds mixture that supplement important functional nutrients to minimize bone mineral deterioration due to menopause in Egyptian women. Methodology: Mixed dietary supplement was formulated from seeds mixture, grounded to be given to patients on yoghurt. Methanolic and water extract were prepared and analyzed using HPLC, to stand on the present bioactive compounds. Analysis for total isoflavons, polyphenols and antioxidant power were done. Twenty nine postmenopausal women, proved to have bone fragility, supplemented by vitamin D and calcium for at least 2 months, were enrolled in the study. Patients were given 40 g of the seeds mixture twice daily for 3 months. The patients were examined by DEXA (dual energy X-ray densitometry) before and after supplementation. Serum minerals, oxidative marker (MDA) and liver and kidney functions were performed. Serum human procollagen 1 N terminal peptide (P1NT) and osteocalcin bone formation markers were estimated. All data were expressed as Mean±Standard Deviation, differences between groups were detected using t-test. The p<0.05 considered statistically significant. Results: Analysis of seed mixture showed high antioxidant capacity, high total isoflavons and polyphenols which are beneficial for bone health. Patient showed significant elevation of T score (p<0.01), P1NT, osteocalcin, zinc, magnesium and decreased MDA after supplementation. Conclusion: It is concluded that the seed mixture showed valuable effect in improving bone mass density of patients. It has no side effect on organ function. It can be considered as a novel supplement for bone health for post menopausal women having bone fragility.