Abstract: The present study aimed to evaluate the antihyperglycemic effects of Foeniculum vulgare extract in streptozotocin (STZ)-induced diabetes in rats. Diabetes was induced via an intraperitoneal injection of STZ (50 mg kg‾1 b.wt.). Control and diabetic animals were treated by F. vulgare extract (100 mg kg‾1) or a similar volume of vehicle. Animals body weight and water intake were monitored and recorded. Blood glucose, amylase, total cholesterol alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine were determined using standard biochemical methods. Results indicated that treatment of diabetic animals with F. vulgare extract restored body weight to be similar to control animals. Additionally, treatment with F. vulgare reduced hyperglycemia in diabetic animals, yet it did not affect glucose levels in control animals. Similarly, treatment of diabetic animals with F. vulgare significantly reduced the diabetes-associated elevation in levels of amylase, total cholesterol, ALT, AST, urea and creatinine suggesting a protective effect on the cardiovascular system, the liver and kidneys. These findings demonstrated the effectiveness of F. vulgare extract in management of STZ-induced diabetes and some of its related complications in animal models. Thus, a more comprehensive characterization of the medicinal potential of F. vulgare will provide understanding of its mechanisms of action and its possible use for diabetes.