Abstract: The effect of antidepressives drugs in brain as outcome bias oxidative stress combined with an antiobesity in hyperglycemic model is unknown and this is the core objective of the present study. L-carnitine (165 mg kg-1) and desvenlafaxine (8.5 mg kg-1) in the presence or absence of sucrose 20% were administered intraperitoneally to young rats for 5 consecutive days. The animals were sacrificed and fresh blood was collected from each to measure the glucose level. The measurement of dopamine, glutathione (GSH), ATPase and lipid peroxidation in brain regions were carried out using validated methods. The animals treated with sucrose combined with L-carnitine or desvenlafaxine did not show hyperglycemia. The levels of dopamine increased in cerebellum/medulla oblongata of the rats that received sucrose in combination with L-carnitine or desvenlafaxine. However, in cortex of groups treated with sucrose alone or combined, dopamine levels were decreased. GSH decreased in all groups treated with sucrose. However, in cerebellum/medulla oblongata GSH witnessed an increase in the absence of sucrose. Lipid peroxidation decreased in all regions of rats that received L-carnitine and desvenlafaxine combined with sucrose. Total ATPase decreased in cerebellum/medulla oblongata in all groups that received sucrose, but increased in cortex in groups that received sucrose in combination with L-carnitine or desvenlafaxine. The animals treated with sucrose combined with L-carnitine or desvenlafaxine did not show hyperglycemia, probably due to inhibition of fatty acid oxidation in brain regions. Reduction of oxidative stress may be involved in these effects.