Abstract: Oral contraceptives (OC) are widely used to prevent ovulation, implantation and therefore pregnancy. The widespread use of the oral contraceptive pills provides an opportunity for assessing their influence on various biochemical parameters i.e., enzymatic, serum lipid and proteins among users. Recent studies have shown its implication in many diseases such as thromboembolic disease, myocardial infarction, circulatory disorders and carcinogenicity. The negative effects on the liver and heart have also been reported due to high serum cholesterol levels among OC for their possible biochemical effects.