Abstract: This study was aimed at finding out if paracetamol influences the pharmacokinetics of ceftriaxone in healthy and salmonella thyphimurium infected Sokoto red goats. In a randomised three-way study, 15 healthy male goats weighing 10-13 kg were divided into three groups of five goats each and each group got either a single intramuscular dose of 1 g ceftriaxone only, 1 g ceftriaxone co-administered with 300 mg paracetamol or 1 g ceftriaxone co-administered with 300 mg paracetamol plus inoculation with Salmonella thyphimurium. Non compartmental Pharmacokinetic parameters were measured in plasma samples by microbiological assay. There was a statistically significant (p<0.01) decrease in the values of absorption half life (0.51±0.004, 0.17±0.02 and 0.14±0.03 h), maximum plasma concentration (Cmax) (45.6±0.19, 19±0.32 and 16.5±0.18 μg mL-1), area under the curve (AUC) (144.1±1.711, 42.24±2.11 and 27.50±0.68 μg/h/mL); and also a statistically significant (p<0.01) increase in the values of elimination half life (0.58±0.012, 5.34±1.85), Volume of Distribution (Vd) (485.3±15.725, 14382.8±4418.9 and 10467±954.83 mL kg-1) and Clearance (Cl) (578.8±6.880, 1992.72±101.89 and 3039.21±72.1 mL/h/kg) when pharmacokinetic parameters were compared for ceftriaxone alone and ceftriaxone co-administered with paracetamol in healthy and infected Sokoto red goats respectively. This study suggests that paracetamol and Salmonella thyphimurium infection alters the plasma disposition of ceftriaxone in healthy and infected Sokoto red goats. We concluded that paracetamol significantly influences the pharmacokinetic profile of ceftriaxone in healthy and infected Sokoto red goats, however further studies are required to confirm these findings and establish the mechanism(s) of interaction.