Abstract: The present study was designed to investigate the effects of alpha Lipoic Acid (LA) against lead acetate induced changes in free radical scavenging enzymes and lipid hydroperoxides in bone marrow of rats. Rats were exposed to lead acetate in their drinking water (500 ppm) for 14 days and alpha lipoic acid was given concurrently (25, 50 and 100 mg kg-1). Blood lead levels, lipid hydroperoxides, protein carbonyl contents and oxidative marker enzymes were estimated. Lead acetate in drinking water had elicited a significant (p<0.05) increase in bone marrow lipid hydroperoxides (LPO) (p<0.05) and Protein-Carbonyl-Contents (PCC). There was a significant (p<0.05) decrease in total antioxidants, superoxide dismutase (p<0.05), glutathione peroxidase (p<0.05), glutathione S-transferase (p<0.05) and catalase levels with lead ingestion. Supplementation of alpha lipoic acid was associated with reduced serum LPO and PCC and a significant (p<0.05) increase in total antioxidants and antioxidant enzyme levels . There was more significant protective effect of bone marrow with 100 mg kg-1 b.wt. LA. The potency of alpha lipoic acid on the reversal of lead induced changes in oxidative biomarkers in bone marrow confirms the importance of lead induced oxidative stress in bone and suggests a therapeutic approach.