Abstract: Arsenic is a well known human carcinogen and has many other toxic effects. Sodium arsenite, a compound of arsenic, capable of inducing genotoxic effects through oxidative stress, is evaluated for its genotoxic effect by the formation of micronuclei in the polychromatic erythrocytes in the bone marrow cells of Wistar rats. Further, the modulatory effects of antioxidants like ascorbic acid and α-tocopherol on arsenic intoxicated rats is investigated. Therefore, the present study was designed to determine whether the oral supplementation of α-tocopherol (400 mg kg-1 body weight) and ascorbic acid (200 mg kg-1 b.wt.) to arsenic-intoxicated rats (100 ppm in drinking water) for 30 days, modulates the genotoxicity caused by arsenic through the formation of micronuclei (p<0.05). The findings suggest that co-treatment of ascorbic acid and α-tocopherol to arsenic-exposed rats protects the antioxidant system and modulates arsenic induced micronuclei formation.