Abstract: Studies have shown the potential of vitamin E in protecting bone against osteoporosis. Osteoporotic animal models were treated with vitamin E in the form of tocotrienols or tocopherols with mixed but overall good results in the bone parameters measured. The common issue raised was which of the two forms of vitamin E has greater potential as anti-osteoporotic agent. For the past decade, we have dedicated our bone researches on examining the role of vitamin E in bone metabolism of various animal models of osteoporosis. In some of our studies both tocopherol and tocotrienol were used as supplements, allowing their effectiveness to be compared. The bone parameters measured included bone resorbing cytokines, bone biochemical markers, bone calcium content, bone histomorphometry and bone strength. The tocopherols were represented by the alpha isomer, while the tocotrienols were represented by several different preparations of tocotrienols. Generally, the tocotrienols were found to be more superior to α-tocopherol in its effects on the bone parameters with a few exceptions. In this review, we explore the capabilities of both forms of vitamin E in their protective effects against osteoporosis. We hope it will shed some light on their potential as anti-osteoporotic agents and facilitate future directions of study on vitamin E.