Abstract: From the past few decades to the future life natural products have played a vital role throughout the world in treating and preventing human disease. The value of natural product in this regard can be based on 3 criteria, (i) The rate of introduction of new chemical entities of wide structural diversity, (ii) The number of disease treated or prevented by these substances and (iii) Their frequency of use in treatment of disease. Microbes have made a phenomenon contribution to the health and well being of people throughout the world. In addition to many primary metabolites such as amino acid, vitamins and nucleotide they also capable of making secondary metabolites, which constitute 1/3 of the pharmaceutical in the market today and provides many essential products to the environment. The new millennium will see further advanced discovery that will keep the sentence Prevention is better than cure.