Abstract: This study examined the anti-inflammatory activity of Pandanus odoratissimus. Anti-inflammatory drugs presently available for the treatment of various inflammatory disorders have diverse and undesirable side effects. In recent years, many active chemicals have been isolated from plants possessing anti-inflammatory activity. The anti-inflammatory activity was estimated by carrageenan-induced acute and formalin-induced chronic paw edema models in rats. The methanolic extract of Pandanus odoratissimus was given in the doses of 25, 50 and100 mg kg -1. The plant extract at the dose of 100 mg kg -1 showed significant anti-inflammatory activity peaked at 3 h where, it caused inhibition for the increase in carrageenan-induced acute (68%) and for the increase in formalin-induced chronic (64.2%) paw edema models in rats. The standard drug was used as diclofenac sodium. As a result methanolic extract of Pandanus odoratissimus was shown to have an anti-inflammatory activity.