Abstract: The main objective of the study was to investigate about the anti hyperlipidemic potential of the ethanolic extract from the fruits of Pedalium murex at doses of 200 and 400 mg/kg/p.o. in high fat diet fed rats. Biochemical parameters like serum total cholesterol (TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), very low density lipoprotein (VLDL) and triglycerides (TG) levels were measured and compared with animals concurrently treated with reference standards Gemfibrozil and Atorvastatin. The ethanolic extract showed a significant decrease in triglycerides (p<0.01), LDL (p<0.001), VLDL (p<0.01), cholesterol (p<0.001) and a significant increase in HDL (p<0.05) levels at the tested doses.