Abstract: A methanol extract of the dried leaves of Chenopodium ambrosioides was investigated for anti-inflammatory and analgesic activities. The extract (300-700 mg kg-1, p.o.) produced a dose related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with the hotplate device maintained at 55°C as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of Chenopodium ambrosioides traditionally for the treatment of painful inflammatory conditions.