Abstract: The study was conducted to find out the effects of atenolol on blood lipid profile of common rabbits (Oryctolagus cuniculus). The administration of an oral dose of 0.6 mg atenolol kg-1 day-1 for 27 days produced a strong dyslipidemia, which was evident by a significant (p<0.05) reduction in mean plasma cholesterol and triglycerides levels, a marked alteration in mean HDL-cholesterol concentration and a non-significant elevated level of LDL-cholesterol. These findings suggest that atenolol is an inappropriate antihypertensive monotherapic agent for patients suffering with the abnormalities of lipid metabolism.