Abstract: In recent years, thermo-sensitive polymer as a novel carrier for controlled-release drug delivery systems has been widely concerned by researchers. With respect to thermo-sensitive polymer, Researchers study on its properties in controlled-release drug delivery systems, such as biodegradation, biocompatibility, Lower Critical Solution Temperature (LCST), biotoxicity, etc. In this study, we mainly review the characteristics of thermo-sensitive polymer, its present research state and further study tendency.