Abstract: In the present study, ten adult domestic rabbits were exposed to an oxidative hair dye for 9 months at weekly intervals. The main blood chemical parameters as well as the total proteins were estimated at 1, 3, 5, 7 and 9 months post-exposure. The exposed rabbits manifested increased serum level of alkaline phosphatase, Aspartate Transaminase (AST), amylase, cholesterol, triglyceride, billirubin, creatinine and urea. Serum level of Alanine Transaminase (ALT), Gamma-glutamyltransferase (GGT), glucose and potassium were decreased as compared with control levels. At all time intervals, the plasma proteins concentration in the exposed rabbits was comparatively decreased. It is concluded that the chemical ingredients of used hair dye are capable of inducing systemic effects in the exposed animals. It is most likely that these effects are achieved after penetration of the skin barrier.