Abstract: The hepatoprotective activity of the ethanol extract of Curcuma longa was investigated against paracetamol (acetaminophen, 4-hydroxy acetanilide)-induced liver damage in rats. Paracetamol at 600 mg kg-1, induced liver damage in rats manifested by statistically increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Histologically, livers from these rats revealed parenchymal necrosis and massive inflammation. Pretreatment of rats with the ethanolic extract of Curcuma longa (100 mg kg-1) prior to paracetamol dosing lowered serum liver enzyme activities. Livers of these rats showed normal histology. These results suggested that ethanolic extract of Curcuma longa has potent hepatoprotective effect against paracetamol-induced liver damages in rats.