Abstract: The water quality parameters of Uta Ewa River, Niger Delta Region, Nigeria at three sites were studied for a period of 12 months (January 2010-December, 2010) to determine the variations in water quality and also to establish its ecological adversity. The water samples were collected and treated using standard analytical methods. Results obtained showed some degree of variation along the water course. The values of the parameters sampled increased from sample site 1 (upstream), to site III. Statistical analysis of the results using one-way ANOVA showed significant difference in site 1 to II1 for temperature, pH, Na, TA, TH, Mg, DO, BOD, TSS and Ca (p<0.05). However, Ec, K, SO4, PO4-P, Cl and TDS showed significant difference (p<0.05) only between two sites (site I to II). The studied parameter did not show any threat to the functioning of the biota as they were in line with the approve limit but frequent monitoring should be done to check sudden upsurge.