Abstract: Two weeks from their parturation, nine lactating buffaloes were used in a 90-d comparative feeding trial to study the effect of uninoculated or inoculated maize silage with Lactic Acid Bacteria (LAB) on their performance. The inoculants were pioneer 1132 which were composed of 100 billion CFU g-1 of crop specific Lactobacillus plantarum and Enterococcus faecium. Animals were similarly grouped into three feeding treatments, according to their weight and milk yield using complete randomized block design. They were introduced to rations containing 60:40 concentrate: roughage ratio as an amount of dry matter equal to 3% of their live body weight. The control group (G1) was fed Concentrate Feed Mixture (CFM) and Rice Straw (RS) as the traditional feeding regimen in summer in Egypt. While, G2 was fed CFM and untreated maize silage and G3 was fed CFM and maize silage inoculated with LAB. Results indicated the digestibility of dry matter, organic matter, crude protein, crude fiber and nitrogen free extract regarding G3 were higher (p>0.05) than those in G1 and G2, while, ether extract digestibility was unaffected by treatments. Milk yield and 4% Fat Corrected Milk (FCM) yield increased significantly with inoculated silage than the other treatments. Milk composition with G3 was higher (p<0.05) for milk total solids, fat and lactose contents than those recorded for G1 and G2. Consequently, G3 produced more yield of milk total solids, fat and protein (p<0.05) than the other groups. Some blood serum parameters were discussed as well. The inoculated maize silage group was better than the other two groups in respect of feed and economic efficiencies.