Abstract: Research has reported that caring for patients with advanced cancer is highly rewarding in the midst of the challenges. The aims of the research were to explore the informal caregivers’ perceptions and determinants of benefits from caregiving to a relative with advanced cancer attending the University of Calabar Teaching Hospital, Calabar, Nigeria. The research employed a cross-sectional descriptive design. Two hundred and ten (210) eligible caregivers providing care to advanced cancer patients were purposively selected. Data were collected using 17 item Benefit Finding Scale (BFS) and were analysed using descriptive and inferential statistics with the help of SPSS 18.0 and PAS 19.0 software. Caregivers reported substantial benefits from caregiving (M (SD) ranged from 2.93 (1.03) becoming more focused on priorities in the deeper sense of life to 3.60 (0.73) appreciation of life and support from other people on a 1-4 Likert Scale). Caregiver’s age, education, religion, marital status and relationship with patients significantly influenced on the level of perceived benefit from caregiving (p≤0.05). There was a statistical (p≤0.01) significant relationship between perceived benefits and the desire to continue caregiving. The results suggest that subsequent research should cover caregivers need for interventions to develop problem-focused coping skills and ability to continue with caregiving role.