Abstract: Polymorphism of rennin angiotensin system has been proved to be implicated in the pathogenesis of several multigenetic diseases including hypertension. To investigate the linkage of insertion/deletion (I/D) polymorphism of Angiotensin Converting Enzyme (ACE) and Met to Thr variant at position 235 of Angiotensinogen (AGT) to the incidence of essential hypertension in a population sample from Egypt. Samples of blood were collected from 203 subjects with matched age and sex (110 hypertensive and 93 normal controls). The polymorphisms of ACE and AGT were investigated by polymerase chain reaction techniques. AGT polymorphism showed significantly increased incidence of hypertension in TT genotype as compared to (MT and MM) genotypes (OR = 2.2, 95%CI 1.0-5.1, p<0.05). Similarly the study of ACE polymorphism declared a minor risk for hypertension in DD compared to (ID and II) genotypes (OR = 1.2, 95% CI 0.7-2.2). No significant association was found between ACE and AGT polymorphism and traditional metabolic risk factors of hypertension and no synergism was found between ACE and AGT genes to be involved in development of hypertension. TT genotype of angiotensinogen polymorphism is a potential risk factor for hypertension in Egyptian subjects.