Abstract: Neoplasia cause several disorders in the affected body, such as suppression of immune function besides emotional and social impairments. Therefore, handling patients can be extremely difficult, offering several challenges in choosing the appropriate treatment option to be used. The right selection of treatment demands special attention. Chemotherapy is usually the standard treatment, although there are many other different therapeutic modalities also used in medicine. The present study is a literature review focusing on the pharmacological properties of propolis, the resinous product collected by the honeybee from different plant sources, which represents a secure and efficient option for biological therapy and cancer prevention.