Abstract: Male breast cancer is an uncommon disease that has been the focus of limited research. In the present study, we specifically investigated whether combination of common genetic variants in the X-ray repair cross-complementation group 1 gene (XRCC1; exon 10, codon 399 Arg/Gln and exon 6, codon 194 Arg/Trp) and loss-of-function deletion polymorphisms in glutathione S-transferases T1 (GSTT1) and M1 (GSTM1), were associated with an altered risk of male breast cancer. Blood samples from 10 males with breast cancer and 15 age- and sex-matched healthy persons were collected. The GSTM1, GSTT1 and XRCC1 genotypes were determined using PCR-based method. The null genotypes of GSTM1 and GSTT1 and 399Gln and 194Trp alleles of XRCC1 assumed as high-risk genotypes and alleles. Statistical analysis showed that the χ2 for linear trend for 0, 1, 2 and 3 putative high-risk genotypes is equal to 5.673 (p = 0.017).