Abstract: The purpose of this research is to study the problem of Non-Hodgkin`s lymphomas in Alexandria, Egypt: incidence rates and trend. Record reviewing for estimation of the annual incidence rates of NHL and their trends. The general incidence rate of NHL was 5.90 in 1995 and reached 8.99 in 2004, with a peak (9.40) in the year 2002. The male incidence of NHL demonstrated an obvious rise from 1995 till 1998, with a slowing from 1999 to 2002, followed by another evident rise from 2003. Females showed an increase in NHL incidence rates from 1995 till 2000, then a decline afterward till 2004. As regards the population from 15-60 years old, there was a rise through the period from 1994-1999 then a drop from 2000 till 2004. In the elderly group, the incidence rate was doubled during the 10 years (from 13.36/100,000 in 1995 to 26.65 in 2004). Conclusively, the incidence of NHL increased steadily from 1995 to 2004 in Alexandria particularly in the elderly population. The importance of developing additional strategies for screening and prevention of NHL, in this group, based on epidemiological evidences is warranted.