Abstract: This study examined, qualitatively and quantitatively, the expression of VEGFs and their receptors, in a group of patients with colorectal cancer and thier correlation to tumour progression. Human colorectal cancer tissues (n = 48) and normal background tissues (n = 48) were obtained after surgery. RNA was extracted from frozen sections for gene amplification. The expression of VEGF-A, B, C and D and their respective receptors VEGFR-1, VEGFR-2 and VEGFR-3 (Flt-1, KDR and FLT-4) were assessed using RT-PCR and the quantity of their transcripts were determined using real-time-quantitative PCR (Q-RT-PCR). VEGF-B (p = 0.001), VEGF-C (p = 0.02), VEGFR-1(p = 0.019) and VEGFR-2 (p = 0.005) were significantly raised in colon cancer tissues compared with the levels detected in normal background tissues. The expression of VEGF-A, VEGF-D and VEGF-R3 in cancer tissues was not statistically significant (p>0.05) from background tissues. The level of the expression of VEGF-C and VEGF-R3 showed no difference in Dukes B and Dukes C. Patients who had cancer penetrating into and through the muscularis propria of the bowel wall and developed nodal involvement (Dukes C), exhibited significantly (p<0.05) higher levels of VEGF-B and VEGFR-2 compared with patients who were node negative (Dukes A and B). We conclude that here is aberrant expression of angiogenic factors VEGF-B and VEGF-C, together with their respective receptors VEGF-R1 and VEGF-R2 (FLT-1 and KDR) in colon cancer compared to normal colon tissues. The high level of expression of VEGF-B and VEGF-R2 were correlated to tumour invasion and nodal involvement (Dukes C) and therefore may have prognostic and therapeutic values in colon cancer patients.