Abstract: Extracts of Trametes elegans were examined for their total phenolic and flavonoid contents and in vitro antiradical potentials. Varying concentrations of the extracts were assessed against 1, 1-diphenyl-2-picrylhydrazyl (DPPH), Nitric Oxide (NO), hydrogen peroxide (H2O2) and hydroxyl (OH) radicals. The result of the total phenolic content expressed in mg gallic acid equivalents per gram of dried extract (mg GAE g–1) revealed that the acetone extract had higher phenolic content (4.79 mg GAE g–1) than the methanol extract. However, the methanol extract had higher total flavonoid (2.27 mg RE g–1) compared to the acetone extract. The extracts displayed appreciable radical scavenging activity to DPPH, NO and H2O2 radicals. The scavenging activities of the extracts were, however, lower to that of the positive control (butylhydroxytoluene). On the other hand, the acetone extract displayed better scavenging activity than the positive control at a concentration of 2 mg mL–1. Result from this study suggest that this underutilized indigenous macrofungus, Trametes elegans, can be exploited as a source of bioactive compounds with antioxidant potentials that can neutralize the damaging effects of free radicals.