Abstract: Heavy metals remain pollutants of great concern to ecologists because of its persistent nature in the environment and its adverse effects on aquatic biota and man. The levels of four heavy metals (Cu, Fe, Zn and Pb) were investigated between January, 2010 and December, 2010 in three sampling stations (Agbara, Imude and Obele) of Ologe Lagoon. The metal contents were measured in water column, sediment and Chrysichthys nigrodigitatus. The highest concentration (972.99±60.93 μg L-1) of Zn in water was recorded in Obele while the lowest value (581.14±42.36 μg L-1) occurred in Imude. The concentrations of the heavy metals in sediments of all the sampling stations was significant (p<0.05). The highest concentrations of Cu (1.25±0.09 μg g-1) and Pb (4.11±0.29 μg g-1) in sediment were recorded in Obele while their lowest values (Cu, 0.55±0.05 μg g-1; Pb, 0.13±0.02 μg g-1) occurred in Imude. The values of the heavy metals in C. nigrodigitatus from Agbara was significantly (p<0.05) higher than the values recorded in the other sampling stations. The highest concentrations of Fe (44.30±1.76 μg g-1), Zn (26.43±1.37 μg g-1) and Pb (0.17±0.04 μg g-1) in C. nigrodigitatus were reported in Agbara while their lowest values (Fe, 24.41±1.01 μg g-1; Zn, 14.82±0.98 μg g-1; Pb, 0.02±0.01 μg g-1) occurred in Obele. Seasonal dynamics had effect on metal content of water and sediment but its effect was not significant (p>0.05) in C. nigrodigitatus except for Cu. This study has shown that Ologe Lagoon contains heavy metals. However, these heavy metals are still within the limits considered safe for human consumption.