Abstract: Background and Objective: Enset constraints are the main challenges for enset production in the growing area as regional and national level of the country. This research study had been developed with an objective of exploring major constraints and farmers’ traditional management system on pre and post-harvest of ensets cultivars in Masha district, Southwest Ethiopia. Materials and Methods: The study kebeles were selected using purposive sampling method and the simple random method was employed to select household informants from each kebele. The data were collected using open and close ended questionnaires, structured and semi-structured interview, filed observation and focus group discussion of household informants. Then the data was analyzed using Microsoft excel spread sheet. Results: The most adaptable and disease and pest resistant varieties of enset selected by indigenous farmers were Gudiro’, ‘Nobo’, ‘Yobo’ and ‘Cherallo’. The productivity of enset was often affected by the accumulation of pests and diseases (28.94%) which was passed through vegetative propagation and followed by lack of appropriate planting materials (15.26%) that used raw material for propagation. The most spoiling and devastating disease and pest of enset crops were mole rats (43.15%) and followed by bacterial wilts (33.29%). Conclusion: Therefore, the university and other stakeholders take the responsible to solve these deteriorate constraints to get surplus products and linkage with market. Awareness creation and deriving scientific approaching technology is crucial for the community using the potential of the area and associated traditional wisdom are paramount importance.