Abstract: Anthracnose fruit rot is the most devastating fungal disease limiting the production and marketing of fresh mango fruits in Nigeria. This study investigated the incidence and severity of anthracnose in mango and its control with plant extracts. A systematic field survey of mango fruit anthracnose was carried out in four locations (Agege, Ayetoro, Ibadan and Ogbomosho) in Southwest Nigeria which fall along mango production belt. The efficacy of botanicals: Annona squamosa, Azadirachta indica and Vernonia amygdalina and synthetic fungicide (Benomyl) in the control of mango anthracnose were evaluated. Data generated from the studies were analyzed using Duncan multiple range test and Pearson's correlation coefficient, respectively at 5% probability. The results showed that 60% of mango trees surveyed were found to be infected with anthracnose and over 34% of fruits produced on those trees were severely infected. Ogbomosho recorded relatively higher percent occurrence (45.9%) and severity (38.1%) of anthracnose. Thirty percent and ten percent concentration levels of Annona squamosa were observed to be highly significant in reducing the incidence of anthracnose when compared with benomyl. Anthracnose disease especially at the postharvest stage is a threat to production and marketing of fresh mango fruits in South West Nigeria.