Abstract: Water extract of Narcissus tazetta bulb were applied on both cytogenetical and ultra structural alteration in Vicia faba roots meristem cells. The experiment was carried out in two variants: (1) continuous treated with the extract for 3, 6, 12, 24 h and (2) treated at 3,6,12 h and followed by recovery time for 72 h. During the treatment, the mitotic activity was inhibited (24 h) depending on the long time of exposure of the extract. All treated resulted in gradual reduction of the mitotic activity. The mitotic activity reached its lowest value after 12 and 24 h. After time of treatment of the extracts, the mitotic activity was inhibited within 24 h and did not resume even after recovery. Treatment caused changes in the phase index, mainly as an increase in the number of prophases. After 24 h of treatment, in all phases, condensation and contraction of chromosomes were observed. After recovery, divisions did not resumed in all treatment, reaching even lower values than the control. C-mitosis, anaphase bridges, chromosome stickiness and micro- nuclei were observed in Narcissus extracts treated faba root-tip cells. In the current work combined both cytogenetical and ultra-structural effects of Narcissus extract on the root meristem cell of Vicia faba plants. Finally, the nucleolus material was extruded from the nucleus into the cytoplasm. Also, disruption of nuclear membranes, chromatin material, mitochondrial cristae disappear, formation huge autophagic vacuoles, and disintegration of organelles were observed.