Abstract: Two greenhouse experiments were conducted in this regard on barley cv. Giza 122 during the period of (2004-2006). α-tocopherol and grasp were used in different concentrations (50, 100, 150 and 250, 500, 1000 mg L-1, respectively), as a post-emergence application either alone or in combination at 3-4 leaf stage. Grasp was extremely effective for controlling grassy weeds rather than broad leaves. However, the associated phytotoxic effect against barley growth was disappointed. The bleaching effect was a distinctive feature throughout. Albeit not permanent, the effect was extended to catch yield and its attributes as compared with hand weeded control. α-tocopherol fairly increased barley growth and its productivity at the different rates of application. Increasing the competitive and allelopathic capabilities of crop plants at the expense of associated weeds could be the reasons behind this fact. Applying α-tocopherol in combination with grasp was more promising than the individual application of either of them. It caused weed growth decreased to a minimum. Barley growth and its productivity increased to their best values in this regard. The chemical analysis revealed on more superiority of the combined application treatments in increasing the photosynthetic pigments (chlorophyll a, b and carotenoids) and amino acids grain yield than the singlet or even hand weeded treatments. It has been suggested that using α-tocopherol in combination with grasp is an excellent tool for reducing the bad effect of the herbicide against growth and development of grassy crops e.g., barley. Such compensatory effect of α-tocopherol might be arise from its ability to quench herbicide's free radicals before they react with intercellular biological systems. Grasp at 500 mg L-1 plus α-tocopherol at 100 mg L-1 is highly recommendable for achieving the best result.