Abstract: Several fungicides are tested individually or in dual combination against four Fusarium species causing potato tuber dry rot in Tunisia. Incorporated into the culture media PDA, the tested fungicides significantly inhibited the mycelial growth of all Fusarium species incubated at 25°C for 6 days; a significant interaction was observed between the both fixed factors (p≤0.05). Applied on potato tubers (tuber immersion for 10 min) prior inoculation, all tested fungicides, combined or not, have significantly reduced by more than 50%, comparatively to the untreated controls, the development of dry rot occasioned by Fusarium sp. after 21 days of incubation at 25-27°C. A significant interaction was observed between the treatments and the Fusarium species (p≤0.05). In natural conditions, tuber treatment by the tested fungicides, prior their definitive storage, has reduced dry rot development by about 50%. A synergistic effect was observed in vitro, in vivo and in situ between the mixed fungicides traduced by a better efficacy, in comparison to their individual effects, showing their compatibility and the promotion of the disease control. These combined fungicides could play a role in an integrated pest management against potato tuber-borne pathogens.