Abstract: There has been increasing reports of ischemic cardiac disease which may be attributed to cardiovascular risk factor as well as adverse effects of some drugs. This study assessed the effect of oral artesunate on the heart morphology. Twenty-four adult wistar rats weighing between 150 and 230 g were separated into four groups, each containing six rats. Group A rats received distilled water while Group C, B and D received 4 mg kg-1 body weight of artesunate orally on day one of the treatment. Group A continued with the same dose for the next 3 days of the treatment. Rats in group B and C received 2 mg kg-1 body weight of artesunate orally for the next 6 and 13 days, respectively. The treated rats in group B, C and D were sacrificed, respectively on 5th, 8th and 15th day of the treatment. The control rats were sacrificed on the 15th day. The heart of each rat was removed and weighed before fixing in 10% formal saline for histological procedures. Results showed normal histological features in control while the treated rats revealed distortions, disaggregation, vacuolation and degenerative changes in cardiac tissue. The heart weight increased significantly (p<0.05) from mean value of 0.41±0.02 in group A to 0.48±0.02 in group B, 0.49±0.03 and 0.57±0.04 g in group C and D, respectively. The observed, distortions, disaggregation, vacuolations and increased heart weight in the treatment groups may impair cardiovascular function and predispose to cardiovascular disorder.