Abstract: Cognitive capacity of human beings has placed natural products in the core of our lives. It has redefined role of science in establishment of its values for society. Evolution of sciences along with various inductivist views and epistemological evidences has changed shape and state of affairs in the world of natural products. As a matter of fact importance of these constituents growing rapidly in our lives. Volatile constituents of Swertia hold many idiosyncratic qualifications, enough to consider them as a promising candidate for their medicinal exploitation. Claim of this genus for a reliable alternative in the present remedial system seems to be acceptable. Many other therapeutic activities have been reported which endorse belief that this genus is going to revolutionize state of affairs in the world of essential oil. This study is devoted to the comprehensive review of recent research work on the genus and is bolstered by epistemic achievements and evidences collected by research community in recent times. The discussion in this study has been devoted to captivating and bewitching role of essential oil of the genus Swertia for various therapeutic purposes. This study gives a core idea of contemporary state of affairs and recent scientific developments.