Abstract: Staphylococcus aureus is a pathogen of major concern because of its ability to cause a diverse array of diseases ranging from minor infections to life threatening septicemia and its ability to adapt to adverse environmental conditions. Methicillin resistance among clinical isolates of S. aureus is still increasing. Knowledge of the risks and benefits associated with antibiotics makes the clinician better able to optimize the patient’s care. Numerous recent publications have documented the fact that despite growing problems with resistance to antimicrobial agents amongst important bacterial pathogens, the number of new antibiotics being brought to the market has shown a precipitous decline over the past several decades, with only a few antimicrobial agents are available for treatment of such infections and none of these possesses ideal characteristics. The rise in antibiotic-resistant microorganisms in recent years has led to an increasing search for new antibiotics.