Abstract: A review of hybridization of some catfishes shows that catfish hybridization among other aspects of biotechnology has continued to raise interest among researchers of various disciplines such as fish biologists, geneticists, aqua culturists, molecular biologists, nutrition scientists and so on. The studies so far reported were from seasoned researchers from several works of life and disciplines who have direct or indirect interest on fish hybridization (especially catfishes). It could be thus, concluded that though there is a dearth in literary work on catfish hybridization considering their numbers and diversities. However, several interesting works can be found across the continents (especially Africa, Asia and North America) that show that catfish hybridization holds a very high potential for the future, a better catfish hybrid is equivalent to a better catfish aquaculture as well as it contribution to global food security.