Abstract: The target of current study was to organize and distinguish panretin-loaded nanocapsules in addition to assess manipulate of this nanoencapsulation on panretin photostability. panretin-loaded nanocapsules (0.6 mg mL-1) were organized by interfacial deposition of polymer (poly-ε-caprolactone) by means of sunflower seed oil. Panretin-loaded nanocapsules obtainable drug content near to the conjectural value, encapsulation efficiencies higher than 99.5%, nanometric mean size with a polydispersity directory underneath 0.20 and pH values flanked by 5.1 and 6. 8. Concerning photodegradation schoolwork, panretin solution demonstrated a half-life time approximately 35 min along with a first order equation, while panretin nanocapsule suspensions demonstrated a half-life flanked by 70 and 95 min consistent with a zero order equation. Panretin-loaded nanocapsules enhanced panretin photostability, separately on the sort of oily used phase and represent a potential system to be included in contemporary or systemic dosage forms included panretin.