Abstract: The material components of the sock provide; impact protection, injury avoidance, anti-frictional, anti-static and anti-bacterial properties. This study comprised an experimental investigation to determine the functional properties including the thermal properties and anti-microbial behavior of socks manufactured using not only traditional cotton or polyester yarns but also yarns made of new kinds of conductive fibers as copper. This study studies the influence of different socks constructions on the functional properties of knitted fabrics made of two types of structures (Rib- Jersey) with conductive fibers effect. The results demonstrated that all tested functional properties influenced by both material type and knitted structure parameters. These findings are an important tool in the design of healthy comfortable socks.